IntroductionHighmyopia(HM)isaseriousformofnearsightednessthatcanleadtosignificantvisionimpairmentandevenblindness.Characterizedbyanelongatedeyeball,thinningofthesclera,andvariouscomplications,includingglaucoma,cataracts,maculardegeneration,andretinaldetachment,HMpresentsagrowingpublichealthconcern,p

IntroductionHighmyopia(HM)isaseriousformofnearsightednessthatcanleadtosignificantvisionimpairmentandevenblindness.Characterizedbyanelongatedeyeball,thinningofthesclera,andvariouscomplications,includingglaucoma,cataracts,maculardegeneration,andretinaldetachment,HMpresentsagrowingpublichealthconcern,p

Background:Asindividualsage,thereproductivetractundergoesnaturaldegenerativechanges,leadingtoanalteredmicroenvironmentandimbalancesinmicrobialcommunities.Thesechangescandecreasereproductivefunctionalityandincreasetheriskofassociateddiseases.Conventionaltreatmentsoftenrelyonhormonereplacementtherapy,

Abstract:ThisarticlepresentsacomprehensivesafetyevaluationofBifidobacteriumanimalissubsp.lactisBLa80,anewprobioticstrainwithpotentialapplicationsinthefoodindustry.Thesafetyassessmentwasconductedthroughinvitroassayssimulatinggastrointestinalconditions,genomicanalysis,anda90-dayoraltoxicitytestinrats.

1.IntroductionChronicidiopathicconstipation(CIC)isacommongastrointestinaldisordercharacterizedbyinfrequentbowelmovements,difficultstoolpassage,andincompleteevacuation.Itsignificantlyimpactspatients'qualityoflifeandismoreprevalentamongwomen.Despitevarioustreatments,somepatientsfailtorespondtoconv

Inrecentyears,theconsumptiontrendofprobioticproductshasbeenincreasingdaybyday,andtheindustrydevelopmenthasenteredaboomperiod.Accordingtosurveydata,theoutputvalueoftheglobalprobioticindustryisexpectedtoexceedUS$77billionin2025.WecareProbioticshasbeenendeavoringfortenyearstodeeplyexplorethefieldofprob