Dysbiosis of Gut Microbiota Is Associated with the Progression of Radiation-Induced Intestinal Injury and Is Alleviated by Oral Compound Probiotics in Mouse Model

Introduction

Irradiation induced intestinal injury is a common side effect of radiation therapy, manifested as damage to intestinal structure and disruption of gut microbiota. Probiotics regulating gut microbiota have the potential to alleviating radiation induced intestinal injury. This study used composite probiotic s to study the intestinal protective effects on irradiated mice.

Study Design

Control: Normal Group

Pro: Probiotics Premix

IR: Irradiation (9 Gy)

IR + Pro: Irradiation + Probiotics

Bifidobacterium animalis subsp. lactis BLa80

Lacticaseibacillus rhamnosus LRa05

Bifidobacterium longum subsp. longum BL21

Lactobacillus acidophilus LA85

Lactiplantibacillus plantarum Lp90

The dosage of probiotics:

100B CFU/day

The days of intervention

10 days before + 4 days after

Main Results

1. Increase survival time and alleviate weight changes

2. Relieve radiation induced intestinal damage and intestinal microbiota disorder

Conclusion

The composite probiotics was administered by gavage for 14 days with dosage of 100B CFU/day to mice exposed to whole-body radiation of 60Co source γ. Mice were found to have improved survival time, alleviated weight loss and intestinal epithelial damage caused by radiation, restored intestinal microbiota disorder, and increased intestinal microbial diversity.