Exploring BC99 in Alcohol-Induced Liver Stress: Clinical Evidence and Mechanistic Insights (NCT06607562)

Alcohol and the Liver: A Modern Health Challenge

Alcohol has become deeply woven into modern social and cultural life—but its overuse poses an escalating global health concern. According to the World Health Organization, more than 2.3 billion people worldwide consume alcohol, and over 75 million live with alcohol-use disorders. Prolonged and excessive drinking is a major cause of alcoholic liver disease (ALD)—now recognized as the second leading cause of liver injury after viral hepatitis—and contributes to over 3 million deaths each year.

Although lifestyle changes such as abstinence and healthy diet remain the mainstay of prevention, they are often difficult to sustain. Increasing evidence highlights the gut–liver axis as a critical pathway linking alcohol metabolism, gut microbiota imbalance, and systemic inflammation.

Previous in vitro and animal studies suggested that Weizmannia coagulans BC99, a robust probiotic strain, may help reduce inflammation and oxidative stress. However, its clinical efficacy in humans had not been established. To address this gap, we conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the protective effects of BC99 on the livers of long-term drinkers.

The Clinical Trial (NCT06607562): Design and Approach

• Participants: 70 long-term alcohol drinkers (18–65 years old, alcohol consumption ≥20 g/day, lasting for more than one year)

• Study duration: 2 weeks.

• Intervention: BC99 group (10B CFU/day) versus maltodextrin placebo group.

• Key measures: blood routine indicators; liver function; renal function; inflammatory factors.

Key Findings

• Significant Improvement in Liver Function: BC99 markedly improved liver health in long-term drinkers — with ALT, AST, γ-GT, and TBil levels significantly reduced, and the proportion of participants with abnormal AST dropping from 34.78% to 0%, indicating a clear protective effect.

• Reducing Inflammation and Metabolic Stress: BC99 decreased abnormal BUN/Cr ratios—a marker of kidney and metabolic stress—and significantly lowered hs-CRP and TNF-α levels, demonstrating its ability to regulate systemic inflammation and metabolic balance.

• Reduced Oxidative Stress: BC99 significantly reduced alcohol-induced oxidative stress by enhancing antioxidant enzyme (SOD) activity and increasing glutathione (GSH) levels, offering strong hepatoprotective benefits against alcohol-related damage.

Overall, these findings show that BC99 can improve liver function, alleviate kidney damage, and modulate inflammatory responses in drinkers, offering a novel microbiome-targeted strategy for managing alcohol-related liver disease.

Smart Protection for Modern Drinkers

In a world where drinking is part of daily life, BC99 helps the body recover and protect itself from alcohol-related stress. Through its action on the gut–liver axis, BC99 turns advanced probiotic science into everyday liver support—helping you enjoy life, with balance and confidence.

Our mission drives us forward: Quality Probiotics, Quality Life.
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